Wednesday, July 23, 2008

Genetic Cause of Statin-Related Muscle Pain Found

British researchers have discovered a genetic variant that causes some people who take cholesterol-lowering statins to have the muscle weakness called myopathy. "We found a variant that affects the transport of statins into the liver," said Dr. Rory Collins, a professor of medicine and epidemiology at the University of Oxford and a leader of the group reporting the discovery in the July 24 online issue of theNew England Journal of Medicine. "That variant produces a high level of blood statins and accounts for the greatest proportion of myopathy in people who use statins."

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