October 18, 2021

Caffeine Plus Acetaminophen Toxic for Some

Very high doses of caffeine and acetaminophen (such as Tylenol), taken together, could lead to liver damage, researchers warn. This combo produces a byproduct enzyme that's toxic to the organ, researchers from the University of Washington report. 

This toxic twosome can occur not only by drinking caffeine while taking acetaminophen, the experts added, but also from large doses of painkillers that combine caffeine and acetaminophen. These painkillers are often used to treat migraines, menstrual discomfort and other conditions. 

"Caffeine can interact with an enzyme that can form a toxic metabolite of acetaminophen in such a way that it increases the formation of that toxic metabolite," said lead researcher Sid Nelson, a professor of medicinal chemistry. "This can result in liver damage," he said. In the study, Nelson's team tested the effects of acetaminophen and caffeine on E. coli bacteria. 

Nelson noted that it takes large qualities of caffeine to produce this reaction. "Normally people wouldn't be ingesting that amount of caffeine," he said. "It would take 10 times the amount of caffeine found in a couple of cups of coffee," Nelson said. Still, for most people, there's no reason to panic, since the chances of caffeine and acetaminophen becoming a toxic mixture remains small, Nelson said. 

"Almost all people don't need to worry about taking caffeine with acetaminophen," Nelson said. Exceptions might be, " those [people] taking high does of caffeine, high doses of acetaminophen, who are possibly alcoholic and/or are epileptic and take certain anticonvulsive drugs," he said.

Read article: https://abcnews.go.com/Health/Healthday/story?id=4508811

October 14, 2021

What does it mean when cancer spreads to the lymph nodes?

Some forms of cancer can spread to other areas of the body as they grow. Cancer can spread to the lymph nodes via a person’s lymphatic system. A person’s lymphatic system is part of their immune system. The lymphatic system is a series of connected nodes and vessels. 

Lymph vessels transport a substance called lymph fluid around a person’s body. Lymph fluid contains white blood cells, which help a person to fight infections. Lymph nodes are small structures that filter foreign substances, such as cancer cells or infections, from the lymph fluid. Lymph nodes also contain white blood cells that attack invading organisms in the lymph fluid. 

When cancer cells appear in a person’s lymph nodes, it means cells have broken away from the original tumor and traveled via the lymph vessels to a lymph node. The presence of cancer cells inside a lymph node indicates that the cancer is spreading. Cancer cells that survive inside the lymph node may then travel to other parts of the body.

Read article: https://www.medicalnewstoday.com/articles/what-happens-when-cancer-spreads-to-the-lymph-nodes

October 3, 2021

Likely cause of Alzheimer’s identified in new study

Worldwide, Alzheimer’s disease is one of the most common forms of dementia. Using mouse models, researchers in Australia have identified one of the likely causes of Alzheimer’s disease. Some have dubbed the finding a “breakthrough.”

By studying the blood-brain barrier, the scientists have come away with a better understanding of why and how Alzheimer’s disease occurs. Their findings suggest potential treatment and prevention options for the neurodegenerative condition. The Centers for Disease Control and Prevention (CDC) estimate that up to 5.8 million peopleTrusted Source in the United States live with Alzheimer’s disease. 

Alzheimer’s disease is a neurodegenerative condition affecting parts of the brain associated with memory, thought, and language. Its symptoms range from mild memory loss to the inability to hold conversations to environmental disorientation and mood changes. 

 Previous research has suggested that various factors — such as age, family history, diet, and environmental factors — combine to influence a person’s risk of Alzheimer’s disease. However, scientists in Australia have recently discovered an additional factor that may be responsible for the development of this neurodegenerative condition.

Read article: https://www.medicalnewstoday.com/articles/likely-cause-of-alzheimers-identified-in-new-study

September 25, 2021

Common painkiller should be investigated for possible risks to developing fetuses, experts say

An international group of 13 scientists has released a statement calling for the health care community to carefully consider the use of acetaminophen (APAP) during pregnancy until the painkiller is thoroughly investigated for any potential impact on fetal development in the womb. Outside the United States, acetaminophen is known as paracetamol.

According to the statement published Thursday in the journal Nature Reviews Endocrinology, a growing body of research shows that "prenatal exposure to APAP might alter fetal development, which could increase the risks of some neurodevelopmental, reproductive and urogenital disorders."

Read article: https://www.cnn.com/2021/09/23/health/acetaminophen-pregnancy-wellness/index.html

September 24, 2021

ARTHRITIS BENEFITS FROM SHARK CARTILAGE THERAPY

Shark cartilage is one of the hottest and most controversial topics debated in medical circles today. Although its mode of action is accepted by established medical principles, the mechanism, or combination of elements responsible for triggering that action, remains a mystery. 

Highly touted for its alleged cancer-fighting abilities (and currently under clinical trials by the Food and Drug Administration [FDA] on terminally ill cancer patients in new Jersey), this natural nontoxic substance is now becoming widely accepted as an effective means for treating less fatal degenerative diseases such as osteoarthritis and rheumatoid arthritis.

“Phenomenal” is how Robert C. Greenburgh, B.S., D.C., E.A.S.A., describes the results he has seen from approximately sixty-five arthritis patients who have used, and continue to use, shark cartilage therapy under his care. Greenburgh explains, “When you have arthritis, you have inflammation; you have vascularity and the creation of new blood vessels. Shark cartilage must be the number one choice with inflammation …. it’s definitely cutting edge.”

Read article: https://seapet.com/health-benefits/shark-cartilage-benefits/

CBD Oil and Tylenol: More Similar Than You Think

How Does Tylenol Work? Tylenol, or acetaminophen, is a drug used to treat mild to moderate pain and fever. While it is mostly associated with headaches, Tylenol can also help relieve pain related to menstrual periods, toothaches, flu/cold symptoms, backaches, and osteoarthritis. 

There are many theories as to how Tylenol interacts with our bodies; however, there is not enough evidence supporting any of these theories to reach a solid conclusion. One of the most widely accepted theories is that acetaminophen works by modulating the endocannabinoid system in the brain. 

CBD Similar? 
If you are familiar with CBD oil, you might have already noticed how Tylenol and CBD are similar. Both CBD and Tylenol are used to relieve pain, and both do so by interacting with our endocannabinoid system. Research suggests that CBD products may, like acetaminophen, inhibit the reuptake of anandamide helping to promote feelings of well-being. 

Is CBD Better Than Tylenol? 
While both may work in similar ways, CBD and acetaminophen are far from being identical. Tylenol carries serious health risks if taken too often or in moderate dosages. Most notably, acetaminophen can result in severe liver damage especially if combined with alcohol. In contrast, CBD produces no harmful side effects or health risks. 

Despite its close relation with cannabis, CBD has no psychoactive properties, so it won’t get users high. Moreover, there is no risk of overdosing or addiction linked to CBD usage.

Read article: https://purerelief.com/cbd-oil-and-tylenol-more-similar-than-you-think/

September 19, 2021

Does CBD help with inflammation? What we know so far

Inflammation, or the inflammatory response, is an aspect of the body’s immune response. While short-term inflammation can be protective, chronic inflammation is linked to several diseases, including heart disease, cancer, diabetes, rheumatoid arthritis, inflammatory bowel disease, and Alzheimer’s. 

Inflammation often goes hand in hand with pain. The most common symptoms of inflammation include pain, heat, redness, and swelling. Typically, inflammation is treated with anti-inflammatory medications, including both non-steroidal anti-inflammatory drugs (NSAIDs) and steroid medications. 

Such medications have risks and side effects, however. Some people choose to take a more preventative approach to treating inflammation, such as consuming an anti-inflammatory diet, and taking anti-inflammatory supplements. Could CBD contribute to a more natural approach to treating inflammation? Current evidence suggests the answer may be yes, but as with many subjects in the cannabis world, more research is needed. 

 How does CBD reduce inflammation? 
Cannabinoids, including CBD, are believed to be anti-inflammatory. Several studies in cells, rodents, and humans support the idea that CBD may be an effective anti-inflammatory, but more research is needed to determine how it works and the best applications for specific types of inflammation. 

Inflammation is a complicated process involving many signalling pathways. The body uses signalling molecules called eicosanoids to initiate the inflammatory response. One of the ways CBD can reduce inflammation is by inhibiting an eicosanoid enzyme called COX2. NSAID medications such as Advil and Aspirin also target COX2 in their method of action. CBD also appears to affect a class of molecules important to the inflammation process called cytokines. CBD tends to reduce the effects of pro-inflammatory cytokines, thereby reducing inflammation.
Read article: https://www.leafly.com/news/health/cbd-for-inflammation-science


September 16, 2021

PAIN: Non-Opioid Treatment

Chronic pain can limit your quality of life and lead to additional, serious health problems. Finding effective treatment is important — as is balancing pain relief with your safety.
Interesting article from the Mayo Clinic reviews pain treatment alternatives. Opioids are NOT the only alternative. Addictive opioids can often be avoided.

Read article: https://www.mayoclinic.org/chronic-pain-medication-decisions/art-20360371

September 15, 2021

Cannabis as a Substitute for Opioid-Based Pain Medication: Patient Self-Report

Introduction: Prescription drug overdoses are the leading cause of accidental death in the United States. Alternatives to opioids for the treatment of pain are necessary to address this issue. Cannabis can be an effective treatment for pain, greatly reduces the chance of dependence, and eliminates the risk of fatal overdose compared to opioid-based medications. Medical cannabis patients report that cannabis is just as effective, if not more, than opioid-based medications for pain.

The Centers for Disease Control (CDC) and Prevention report that “[o]pioids (including prescription opioid pain relievers and heroin) killed more than 28,000 people in 2014, more than any year on record.” Unfortunately, this statistic has done little to curb the prescribing and consumption patterns for prescription opioids. The CDC estimates that, “since 1999, the amount of prescription opioids sold in the United States nearly quadrupled, yet there has not been an overall change in the amount of pain that Americans report. Deaths from prescription opioids—drugs like oxycodone, hydrocodone, and methadone—have also quadrupled since 1999.

September 10, 2021

long-term cannabis use does not increase sensitivity to pain

September 10, 2020 Source: University of British Columbia Okanagan campus
 Summary: A recent study examining pain among cannabis users suggests that -- unlike long-term opioid use -- regular cannabis use does not appear to increase pain sensitivity.

"This study should come as good news to patients who are already using cannabis to treat pain," says co-author Zach Walsh, who leads the UBC Therapeutic Recreational and Problematic Substance Use Lab which hosted the study. "Increases in pain sensitivity with opioids can really complicate an already tough situation; given increasing uptake of cannabis-based pain medications it's a relief that we didn't identify a similar pattern with cannabinoids." 

St. Pierre's study explored differences in measures of pain intensity and tolerance. The authors speculated that people who report frequent cannabis use would demonstrate greater experimental pain sensitivity but instead found no differences. "There is a different effect from opioid users; sustained use of opioids can make people more reactive to pain. We wanted to determine if there was a similar trend for people who use cannabis frequently," says St. Pierre. "Cannabis and opioids share some of the same pain-relief pathways and have both been associated with increases in pain sensitivity following acute use." 

The risk of addiction, overdose and opioid-induced hyperalgesia -- where someone becomes more sensitive to pain -- are major issues when it comes to using opioids to manage chronic pain, St. Pierre says. A patient with hyperalgesia might then increase their dosage of the opioid to manage the pain, further increasing the risk of addiction.

Read article:
 https://www.sciencedaily.com/releases/2020/09/200910120105.htm

Does CBD oil work for chronic pain management?

Many people use cannabidiol (CBD) to relieve pain. Understanding CBD can help overcome the stigma associated with it. CBD oil is derived from the cannabis plant. People report using this oil for relief from pain, anxiety, depression, and sleep disorders. 

There is limited evidence from human studies to support the benefits of CBD oil, due to restrictions on the use of and research on cannabis. As cannabis is becoming legalized in various regions, research is gaining momentum and shows some promising results. In this article, we look at how CBD oil works and how people use it to relieve chronic pain. 

 CBD is one of more than 100 compounds found in cannabis, called cannabinoids. Many plants contain cannabinoids, but people most commonly link these compounds to cannabis. Unlike other cannabinoids — such as tetrahydrocannabinol (THC) — CBD does not produce a euphoric “high.” This is because CBD does not affect the same receptors as THC. 

The human body has an endocannabinoid system (ECS) that receives and translates signals from cannabinoids. It produces some cannabinoids of its own, which are called endocannabinoids. The ECS helps regulate functions such as sleep, immune-system responses, and pain. When THC enters the body, it produces a “high” feeling by affecting the brain’s endocannabinoid receptors. This activates the brain’s reward system, producing pleasure chemicals such as dopamine.

September 9, 2021

Study: CBD does not cause liver damage

CBD products do not cause liver damage when taken orally, according to a new study from Validcare. The seven-month analysis evaluated the impact of CBD on liver health through clinical trials involving 839 participants. 

The study was conducted at the FDA’s request to inform the federal agency’s developing regulatory approach to CBD products. Twelve CBD industry companies helped fund the study, provided certificates of authenticity and recruited survey participants.

Stakeholders ranging from policymakers to food manufacturers have been eager for the FDA to clarify its stance on CBD, which is currently not regulated for use in products.

Read article: https://www.fooddive.com/news/study-cbd-does-not-cause-liver-damage/597311/

September 8, 2021

11 Hydroxy Metabolite: The Secret to Why Edibles Hit Harder

How Δ9-THC Effects Us When Smoked: When smoking, Delta 9 THC is taken in through the lungs, where it then passes into the bloodstream. Due to the plethora of blood vessels in the lungs and the bio-availability of the inhaled smoke, this lets the THC kick in quicker; immediate effects are almost instantly shown after inhalation, with more long-term effects settling in between five to fifteen minutes. 

How Δ9-THC Effects Us When Eaten: Alternatively, when Δ9-THC is eaten, it passes through the gastrointestinal system, including the liver, where our bodies break it down into the metabolite 11-OH-THC, or “11 Hydroxy THC”. Interestingly 11 Hydroxy THC does not naturally appear in the cannabis plant, nor will it ever come from smoking cannabis; it only forms as a metabolite after being ingested (and, as mentioned above, will only come from cannabis that has been properly decarboxylated; eating raw cannabis will not get you high). 

Why Edibles Hit Harder: When we smoke cannabis, the THC we intake passes very directly into our bloodstream but in a less-than-efficient manner. Being an oil-soluble chemical, THC won’t break down in the watery human bloodstream, meaning that even with as strong as some smokes can be, our bodies still aren’t getting the full potential of the cannabis being smoked. The human digestive system has no such qualms and will set to work metabolizing anything we ingest that it can handle; the breakdown of these complex compounds results in what is known as metabolites.

Read article:  https://highthere.com/cannabis/11-hydroxy-metabolite/

September 7, 2021

Alzheimer’s: Is brain inflammation the missing trigger?

(NOTE: see articles on endothelial inflammation)

“Many [older adults] have amyloid plaques in their brains but never progress to developing Alzheimer’s disease. We know that amyloid accumulation on its own is not enough to cause dementia — our results suggest that it is the interaction between neuroinflammation and amyloid pathology that unleashes tau propagation and eventually leads to widespread brain damage and cognitive impairment.”// The study appears in Nature Medicine
Trusted Source. 

Neuroinflammation: 
While scientists have observed neuroinflammation in people with Alzheimer’s before, the new study reveals for the first time its critical role in the development of the disease. The research finds that activating the brain’s immune cells — its microglial cells — promotes the spread of tangled tau proteins that comprise amyloid plaque. 

Heather M. Snyder, Ph.D., Alzheimer’s Association vice president of medical and scientific relations, who was not involved in the study, explained the purpose of neuroinflammation to Medical News Today. The Alzheimer’s Association contributed funding to the research. “Inflammation has an important role in fighting off infection and other pathogens in the body, including in the brain and central nervous system,” said Snyder. Microglia “help clear debris (damaged neurons, infections) from the brain.” 

“However,” adds Dr. Snyder, “a sustained inflammatory response, or a change from acute to chronic neuroinflammation, may contribute to the underlying biology of several neurodegenerative disorders.” Inflammation is not by itself associated with cognitive impairment, Dr. Pascoal told MNT. “However,” he said, “when neuroinflammation converges with amyloid pathology, the interaction potentiates tau pathology. As a consequence, the coexistence of these three processes in the brain — amyloid, neuroinflammation, and tau pathology — determines cognitive deterioration.”

Read article: https://www.medicalnewstoday.com/articles/alzheimers-is-brain-inflammation-the-missing-trigger

https://solerahealth.blogspot.com/2019/04/inflammation-in-atherosclerosis.html

https://solerahealth.blogspot.com/2019/04/inflammation-in-atherosclerosis.html

September 5, 2021

How to Try CBD for Depression

Experts believe that CBD’s potential benefits for depression are related to its positive effect on serotonin receptors in the brain. Low serotonin levels are likely connected to depression. CBD doesn’t necessarily boost serotonin levels, but it may affect how your brain’s chemical receptors respond to the serotonin that’s already in your system. 

A 2014 animal study found that CBD’s effect on these receptors in the brain produced both antidepressant and anti-anxiety effects. A more recent 2018 review Trusted Source of existing studies concluded that CBD has anti-stress effects, which may reduce depression related to stress. 

As mentioned, this is an area that’s still being actively studied, and new research and reviews are published every year. As researchers begin to better understand CBD and its potential benefits or concerns, information about how to most effectively use the product will continue to change.

Read article: www.healthline.com/health/cbd-for-depression

September 4, 2021

How Does CBD Affect the Brain? Impact of Cannabidiol on Brain Function

While all other active compounds of the plant interact with two cannabinoid receptors in the nervous system, CB1 and CB2, Cannabidiol has very little effect on both. CB1 receptors are found in different regions of the brain, including those responsible for controlling emotion, pain, cognition, and memory. CB2 receptors, on the other hand, regulate inflammatory responses and bolster the immune system. 

CBD stimulates the endocannabinoid system to produce more of its own cannabinoids and slows their breakdown.  Delta-9-Tetrahydrocannabinol (THC), on the other hand, binds to CB1 and CB2 receptors, activating them and thus changing a person’s thinking, memory, pleasure, and pain perception, and concentration. These effects contribute to what we describe as a marijuana high. 

Interestingly, CBD may also alter the effects of THC by blocking the CB1 receptors in places where THC taps. In higher doses, THC can induce anxiety and paranoia in some users, which is why many people are afraid to try weed. But strains that are high in CBD tend to mitigate these effects, allowing you to enjoy the benefits of marijuana without a disturbance.

Read article: https://cfah.org/cbd-effects-on-brain

September 2, 2021

Why Avoid Back Surgery at all Costs-Try this instead. Avoid Back Fusions.

Famous Physical Therapists Bob Schrupp and Brad Heineck give their opinion on why you should avoid back surgery at all costs. Especially back fusions. They advocate trying a conservative approach first.

Watch video: https://www.youtube.com/watch?v=tqJxO-C0LB0&t=42s

Antibiotic Use On Farms Linked To Rising Rates Of Drug-Resistant Infections

As families across America adorn their dinner tables with plump, juicy turkeys this Thursday, they've likely given little thought to what their future food previously consumed.

By the end of this year, an estimated 248 million turkeys will have been raised in the U.S., approximately 83 percent on farms that produce more than 60,000 turkeys each and most eating a diet that includes low doses of antibiotics. This common agricultural practice results not only in more meaty birds, according to experts, but also in greater risks to public health.

"Antibiotic use in animals comes back to haunt people," said Stuart Levy, a Tufts University microbiology professor who focuses on antibiotic resistance. He recently co-authored a review of the evidence showing how animal antibiotics affect human health -- via direct contact and indirectly via food, water, air and anywhere manure goes.

Levy and other experts warn that the widespread use of antibiotics to treat sick livestock, prevent the spread of disease in cramped conditions or simply promote animal growth has fueled the proliferation of antibiotic-resistant bacteria, which is making many infections in humans harder to treat. As The Huffington Post reported in August, some human infections now resist multiple antibiotics.

Livestock receive an estimated 80 percent of the nation's antibiotics. According to the U.S. Food and Drug Administration, about 90 percent of those antibiotics are consumed by the animals in their feed or water -- usually at very low doses. What doesn't kill bacteria, however, often makes them stronger and more likely to defeat medicine's current range of weaponry.

"Turkey is one of the most frequently contaminated meats," said Ellen Silbergeld, a professor at Johns Hopkins School of Public Health. She highlighted a study from earlier this year that found 77 percent of turkey samples collected from U.S. supermarkets. Of those, approximately 96 percent were resistant to at least one antimicrobial agent. A few of other hint at the growing problem of multidrug-resistant infections, such as (MRSA), in meats sold to consumers, including turkey. 


READ ARTICLE

Everything you need to know about tofu

Tofu is made from soybean curds. It is naturally gluten-free and low in calories. It contains no cholesterol and is an excellent source of iron and calcium.

Soy isoflavines have been found to help reduce levels of LDL "bad" cholesterol, although it does not seem to increase HDL or "good" cholesterol levels.

 Several clinical and experimental investigations have antioxidant properties that may inhibit the growth of cancer cells.

 People with type 2 diabetes often experience kidney disease, causing the body to excrete an excessive amount of protein in the urine.

 Soy isoflavones may help reduce bone loss and increase bone mineral density, especially after menopause. They have also been reported to reduce some other symptoms of menopause. 

https://www.medicalnewstoday.com/articles/278340.php

Is the use of cholesterol in mortality risk algorithms in clinical guidelines valid? Ten years prospective data from the Norwegian HUNT 2 study


Many clinical guidelines for cardiovascular disease (CVD) prevention contain risk estimation charts/calculators. These have shown a tendency to overestimate risk, which indicates that there might be theoretical flaws in the algorithms. Total cholesterol is a frequently used variable in the risk estimates. Some studies indicate that the predictive properties of cholesterol might not be as straightforward as widely assumed. Our aim was to document the strength and validity of total cholesterol as a risk factor for mortality in a well-defined, general Norwegian population without known CVD at baseline.


Our study provides an updated epidemiological indication of possible errors in the CVD risk algorithms of many clinical guidelines. If our findings are generalizable, clinical and public health recommendations regarding the ‘dangers’ of cholesterol should be revised. This is especially true for women, for whom moderately elevated cholesterol (by current standards) may prove to be not only harmless but even beneficial.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303886/

August 27, 2021

What to know about COPD and COVID-19 vaccinations

COPD refers to a group of conditions that limit the functioning of the airways and causes trouble breathing. Evidence suggests that in 2018, more than 16 million people in the U.S. reported a diagnosis of COPD. As COVID-19 may lead to mild to severe respiratory problems, people with COPD are at a higher risk of more severe illness from COVID-19 due to their existing lung problems. 

Evidence suggests that the COVID-19 vaccines available to those in America are safe and effective. Research also indicates that the vaccines are suitable and efficacious for people living with COPD. In this article, we will discuss the safety and efficacy of the available COVID-19 vaccines for people living with COPD.

Read article: https://www.medicalnewstoday.com/articles/copd-and-covid-19-vaccine

August 23, 2021

Opioids From Strongest to Weakest

Opioid addiction has dominated news headlines and flooded the treatment industry in the last few years. The problem is so severe that approximately 130 people die each day from an opioid-related overdose. Additionally, in 2017, 1.7 million people in the United States were addicted to prescription opioids and approximately 652,000 suffered from heroin addiction.

 Even though many of the opioids on this list can be prescribed by a physician, it doesn’t mean that they are safe. In fact, all opioids are highly addictive when abused. Despite the high potential for abuse, the CDC reports that in 2017, the average opioid prescribing rate was 58.7 prescriptions per every 100 people.

 Most opioids are controlled substances that have a high potential for abuse. When abused, a person’s tolerance increases and the body requires more and more of the drug. Then, the body becomes physically dependent on the drug to avoid going into opioid withdrawals. However, not all opioids are the same. Here are the most common opioids of abuse, listed from strongest to weakest.

Read article: https://paxmemphis.com/opioids-from-strongest-to-weakest/

People with fibromyalgia substituting CBD for opioids to manage pain

The cannabis-derived substance provides fewer side effects, with less potential for abuse.
Previous research shows that some people substitute medical cannabis (often with high concentrations of THC) for opioids and other pain medications, reporting that cannabis provides better pain relief and fewer side effects. However, there is far less data on CBD use. 

“CBD is less harmful than THC, as it is non-intoxicating and has less potential for abuse,” said Kevin Boehnke, Ph.D., a research investigator in the Department of Anesthesiology and the Chronic Pain and Fatigue Research Center. “If people can find the same relief without THC’s side effects, CBD may represent a useful harm reduction strategy.” 

 Boehnke and his team surveyed people with fibromyalgia about their use of CBD for treatment of chronic pain. “Fibromyalgia is not easy to treat, often involving several medications with significant side effects and modest benefits,” Boehnke explained. “Further, many alternative therapies, like acupuncture and massage, are not covered by insurance.” 

 For this study, the team focused on 878 people with fibromyalgia who said they used CBD to get more insight into how they used CBD products. The U-M team found that more than 70% of people with fibromyalgia who used CBD substituted CBD for opioids or other pain medications. Of these participants, many reported that they either decreased use or stopped taking opioids and other pain medications as a result. 

“I was not expecting that level of substitution,” said Boehnke, noting that the rate is quite similar to the substitution rate reported in the medical cannabis literature. People who said they used CBD products that also contained THC had higher odds of substitution and reported greater symptom relief.

Cannabis as a Substitute for Opioid-Based Pain Medication

Introduction: Prescription drug overdoses are the leading cause of accidental death in the United States. Alternatives to opioids for the treatment of pain are necessary to address this issue. Cannabis can be an effective treatment for pain, greatly reduces the chance of dependence, and eliminates the risk of fatal overdose compared to opioid-based medications. Medical cannabis patients report that cannabis is just as effective, if not more, than opioid-based medications for pain. 

Materials and Methods: The current study examined the use of cannabis as a substitute for opioid-based pain medication by collecting survey data from 2897 medical cannabis patients. 

Discussion: Thirty-four percent of the sample reported using opioid-based pain medication in the past 6 months. Respondents overwhelmingly reported that cannabis provided relief on par with their other medications, but without the unwanted side effects. Ninety-seven percent of the sample “strongly agreed/agreed” that they are able to decrease the amount of opiates they consume when they also use cannabis, and 81% “strongly agreed/agreed” that taking cannabis by itself was more effective at treating their condition than taking cannabis with opioids. Results were similar for those using cannabis with nonopioid-based pain medications. 

Conclusion: Future research should track clinical outcomes where cannabis is offered as a viable substitute for pain treatment and examine the outcomes of using cannabis as a medication assisted treatment for opioid dependence.

How Long Does CBD Oil Take to Work? Ask a Pharmacist

When asking how long it takes for CBD to work, you first need a basic understanding of what CBD is, and how different variables can impact how it works for you. In general, it takes CBD within 30 minutes to 2 hours to absorb into the bloodstream, depending on the method of consumption.1 But other factors like the amount of CBD you take, how often you take it, and the product quality can all play a role in how long it takes to feel CBD, and how long CBD will Stay In Your System. 

The major caveat to all of these questions are that it really depends on your body, your goals, and expectations. Some people may notice results from CBD within a matter of days, while others may require weeks of consistent use before beginning to notice a difference. Consistency and patience are required before you can make any judgements about whether CBD works for you.

If you find yourself wondering, “How long does it take for CBD oil to work?” read on as we explore the variables.

Is CBD Oil Legal? Legal Status of CBD in 50 States in 2021

Cannabis has had a rocky history in the United States. Starting in the 1920s, various states banned the use of the herb, which eventually leads to the federal government banning the plant’s use under any circumstances for several decades. 
 Only in the 1970s did regulators consider the medical applications of the plant and began rolling out medical programs around the country. CBD wouldn’t be recognized as a medicinal agent for quite some time, and regulators saw all forms of the cannabis plant as a drug — including hemp. 

Now, as we inch our way towards a new decade, the landscape is much different. The federal government recently passed a bill that clearly differentiated two forms of the cannabis plant — hemp and marijuana — arguing that the hemp variety can’t produce the psychoactive high inherent to marijuana. They crossed hemp off the list of restricted substances, giving people open access to the plant for the first time in over 80 years. 

But the landscape is continually changing, each state has its own laws to work out in response to this federal change — and some are much slower than others. In this article, we’ll discuss what makes some sources of CBD legal, while others remain a Schedule I controlled substance. Let’s get started with an overview of what CBD actually is.
Read article: https://cfah.org/cbd-legal-states/

August 22, 2021

Are chicken eggs good or bad for my cholesterol?

Chicken eggs are an affordable source of protein and other nutrients. They're also naturally high in cholesterol. But the cholesterol in eggs doesn't seem to raise cholesterol levels the way other cholesterol-containing foods do, such as trans fats and saturated fats. Most healthy people can eat up to seven eggs a week without increasing their risk of heart disease. Some studies have shown that this level of egg consumption may even help prevent certain types of stroke and a serious eye condition called macular degeneration that can lead to blindness. // 

But if you have diabetes, some research suggests that eating seven eggs a week increases heart disease risk. However, other research failed to find the same connection. Still other research suggests that eating eggs may increase the risk of developing diabetes in the first place. More research is needed to figure out the exact link between eggs, diabetes and heart disease.
Read article: https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/expert-answers/cholesterol/faq-20058468

Is It Gas Pain or a Heart Problem?

It’s perfectly normal to pass gas between 10 and 20 times a day. At the same time, it’s understandable to be worried if you feel chest pain after eating a meal. After all, if it’s gas, aren’t you supposed to feel it in your gut, not near your heart? 

 While you may be simply feeling the sensation of gas pain in your chest, this pain could also indicate a serious heart issue. Learn how to determine if you or a loved one needs to seek medical attention. 

 Please note, if you are still unsure if you are experiencing gas pain or a heart problem after reading this article, play it safe and go to the nearest emergency room to receive care. Know when it’s gas: You may feel pain in your chest if gas has gathered in your stomach or in the left portion of your colon. Gas can become trapped in your digestive tract when you swallow too much air. There are other food-related reasons why you may feel gas pain near your chest.

They include: 
A food intolerance may be upsetting your digestive system and causing you to build up gas. 
Artificial sweeteners can cause digestive upset symptoms, including gas pains.
Carbon dioxide gas in carbonated drinks, like soda, can cause an air bubble feeling in your chest. 
Eating a lot of fiber-rich foods can result in too much fiber in your gut, producing gas for longer periods. 
Food poisoning can cause gas pain near your heart, along with fever, nausea or vomiting, diarrhea or blood in your stool.
Read article: https://blog.bonsecours.com/heart/gas-pain-vs-heart-problem/

How Long Does Heart Bypass Surgery Last?

When asking, “how long does heart bypass surgery last?” It’s very important to understand the different types of bypass grafts used. The most important one is called the LIMA (left internal mammary artery) and is an artery that runs on the inside of the chest wall on the left side of the body. 

The other type of bypass graft we will talk about is called an SVG (saphenous vein graft) that is taken from the leg and is a vein used as a bypass. Although there are other types of artery bypasses (radial, right mammary), for the purposes of this article I will concentrate on the LIMA and the SVG, as they are by far the most commonly used in the US.

Now we can start to answer the question “how long does heart bypass surgery last?” Studies have shown that the LIMA graft is around 95-99% likely to be open and working at 1 month after operation, 90-95% likely to be open at 1 year – 5 years, and around 80-90% (even greater in some studies) likely to be open at >10 years. These studies show that the LIMA graft has excellent not only short, but long term results. Unfortunately there is only 1 LIMA graft but often patients have many blockages requiring bypass so we have to use veins or other arteries.
Read article: https://myheart.net/articles/how-long-does-heart-bypass-surgery-last/

August 19, 2021

N95 Vs. KN95 Masks: What's the Difference?

To be clear, this does not mean COVID-19 vaccines are ineffective. Two preprint studies (meaning they have not yet been peer-reviewed) in Israel, published on July 16, found the Pfizer/BioNTech vaccine is 81 percent effective at preventing COVID-19. Still, you should mask up–and N95 and KN95 masks are some of the best for protection against the deadly Delta variant (but other masks work, too!). 

You've probably been wearing a mask when out in public for most of the past year, but are you still wearing the right one? Since new mutations of COVID-19, like the Delta variant, are even more contagious, it's important to wear masks with a high filtration capacity and a snug fit. N95 and KN95 masks best fit that bill. But what exactly are N95 and KN95 masks, what are the differences between them, and which mask should you ultimately purchase? Here are the facts. 

The main differences are the looks and regulating bodies that control the masks. The National Institute for Occupational Safety and Health (NIOSH) regulates N95 masks, putting each mask prototype from various manufacturers through a rigorous testing process. Meanwhile, the Chinese government regulates KN95 masks. 

Here's the Bottom Line: For the average person, N95 masks and KN95 masks have negligible differences. If you're not a health care worker, either should suffice for you. But if you can't find either kind of mask, consider double masking with a surgical mask beneath your cloth mask.

https://www.popularmechanics.com/science/health/a35383193/n95-vs-kn95-mask-differences/